Human insulin and unawareness of hypoglycemia.

Unawareness of hypoglycaemia and human insulin.

Islet Transplantation for Hypoglycemia Unawareness/Severe Hypoglycemia: Caveat Emptor.

Current estimates are that 1.25 million Americans have type 1 diabetes (T1D) (1) caused by the gradual loss of nearly all pancreatic insulin-producing b-cells via a presumed T cell–mediated autoimmune process (2). Eventually, all with T1D display severely impaired endogenous insulin production (3) and are dependent upon injected insulin for survival. Because subcutaneously administered insulin ...

Theophylline improves hypoglycemia unawareness in type 1 diabetes.

Iatrogenic hypoglycemias and the subsequent occurrence of hypoglycemia unawareness are well-known complications of intensive insulin therapy in type 1 diabetic patients that limit glycemic management. From a pharmacological point of view, the adenosine-receptor antagonist theophylline might be beneficial in the management of hypoglycemia unawareness. Theophylline stimulates the release of catec...

Hypoglycemia unawareness in Type 1 diabetes suppresses brain responses to 1 hypoglycemia 2 3

28 Background: Amongst non-diabetic individuals, mild glucose decrements alter brain activity in 29 regions linked to reward, motivation and executive control. Whether these effects differ in T1DM 30 patients with and without hypoglycemia awareness remains unclear. 31 Methods: 42 individuals (13 healthy control subjects (HC), 16 T1DM individuals with 32 hypoglycemia awareness (T1DM-Aware) and 1...

Experiences, views, and support needs of family members of people with hypoglycemia unawareness: interview study.

OBJECTIVE Hypoglycemia unawareness (HU) affects ~25% of people with type 1 diabetes. People with HU are often reliant on family to detect hypoglycemia and treat severe episodes. We explored the impact of HU on family members' lives, their involvement in preventing and managing hypoglycemia, and their information and support needs. RESEARCH DESIGN AND METHODS This study employed an exploratory, ...